产品货号：
Z36098
中文名称：
PMS2抗体
英文名称：
Anti-PMS2 Antibody (Clone#1204)
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PMS2 Antibody (Clone#1204) |
| 指标别名 | PMS1 homolog 2;mismatch repair system component;HNPCC4;MLH4;MMRCS4CL;PMSL2;PMS2 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | ELISA,SDS-PAGE,WB |
| 基因名称 | PMS2 |
| 克隆号 | 1204 |
| 抗体来源 | Mouse |
| 免疫原 | This protein A purified monoclonal antibody was produced by repeated immunizations with recombinant human PMS2 corresponding to the first 133 amino acid residues of the protein.The clone was produced using conventional hybridoma technology. |
| 计算分子量 | 96kDa |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This is an protein A purified antibody from ascites fluid directed against PMS2-134 and reacts with full length version of PMS2 in human and hamster tissues.The epitope was putatively mapped to amino acids 58-81 of human PMS2.BLAST analysis indicates that this sequence is 100% identical for human,mouse,rat and chimpanzee.No specific information is available for reactivity with PMS2 protein from other sources. |
| 浓度 | 1.0mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | PMS2 is a highly conserved nuclear protein involved in mismatch repair during DNA replication and has been identified to be composed as a heterodimer of PMS2 and MLH1.PMS is part of the BRCA1-associated genome surveillance complex (BASC),which contains BRCA1,MSH2,MSH6,MLH1,ATM,BLM,PMS2 and the RAD50-MRE11-NBS1 protein complex.This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains.Defects in PMS2 are the cause of hereditary non-polyposis colorectal cancer type 4 (HNPCC4),Turcot syndrome (an autosomal dominant disorder characterized by malignant tumors of the brain associated with multiple colorectal adenomas) and supratentorial primitive neuroectodermal tumors with cafe-au-lait spots (SNTCL).The human PMS2 gene encodes an 862 aa,96kDa polypeptide. |
| Uniprot ID | P54278 |
| 基因名全称 | Mismatch repair endonuclease PMS2 |
| 推荐稀释比 | ELISA:1:5,000 - 1:20,000 WB:1:500 - 1:2,000 |
相关搜索：PMS2抗体，PMS2单抗，Anti-PMS2 Antibody (Clone#1204)